![]() ![]() Among included studies, there were seven papers published in the past 5 years, eight papers about Caucasian, two papers about Asian, five papers with high-quality, two abstracts without NOS score. The characteristics included in the article are shown in Table 1. All studies were limited to English language and the retrieval strategy of Pubmed as follow: (((((Mean Platelet Volumes OR Platelet Volume, Mean OR Platelet Volumes, Mean OR Volume, Mean Platelet OR Volumes, Mean Platele))) OR “Mean Platelet Volume”)) AND (((((Hydroxymethylglutaryl CoA Reductase Inhibitors OR Inhibitors, Hydroxymethylglutaryl-CoA Reductase OR Reductase Inhibitors, Hydroxymethylglutaryl-CoA OR Inhibitors, HMG-CoA Reductase OR Inhibitors, HMG CoA Reductase OR Reductase Inhibitors, HMG-CoA OR HMG-CoA Reductase Inhibitors OR HMG CoA Reductase Inhibitors OR Statins, HMG-CoA OR HMG-CoA Statins OR Statins, HMG CoA OR Inhibitors, Hydroxymethylglutaryl-CoA OR Hydroxymethylglutaryl-CoA Inhibitors OR Inhibitors, Hydroxymethylglutaryl CoA OR Statins OR Inhibitors, Hydroxymethylglutaryl-Coenzyme A OR Hydroxymethylglutaryl-Coenzyme A Inhibitors OR Inhibitors, Hydroxymethylglutaryl Coenzyme A)) OR (*statin OR atorvastatin OR rosuvastatin OR pravastatin OR simvastatin OR statin))) OR “Hydroxymethylglutaryl-CoA Reductase Inhibitors”). We also searched reference lists of related articles by hand to obtain more studies. To achieve the maximum sensitivity of the search strategy, we used appropriated free text and thesaurus terms including “Hydroxymethylglutaryl CoA Reductase Inhibitors”, “statin”, “mean platelet volume”. Literature was retrieved by formal search of electronic databases (PubMed, Embase and Cochrane Library) without date limitation. This systematic review and meta-analysis are reported in accordance with the Preferred Items for Systematic Reviews and Meta-analysis (PRISMA) Statement. Therefore, statin therapy could reduce MPV significantly and exhibited antiplatelet activity, which is of great importance in clarifying the clinical significance of MPV in cardiovascular events and the prevention of cardiovascular events. Drug type, sample size, ethnicity, mean age and quality of included article were sources of heterogeneity. Subgroup analysis suggested that when ≥55 years, this decrease did not occur. Consolidating relevant data and comparing the changes of MPV before and after statin treatment, we found that statin could decrease MPV, which was statistically significant ( P=0.0001). Eventually, we included ten studies, a total of 1189 patients with the risk of cardiovascular diseases. Two reviewers independently assessed eligibility and quality of the studies. ![]() Relevant studies were selected by searching electronic databases (PubMed, Embase and Cochrane Library) and reference lists of related articles by hand. To further improve the clinical significance of MPV in those patients and explore new function of statin, we conducted this research. Many studies have demonstrated the effects of statin therapy on platelet, but it is controversial that whether statin could reduce mean platelet volume (MPV) in patients with the risk of cardiovascular diseases. Access content during the Covid-19 pandemic. ![]()
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